Research Architecture

Innovative four-phase research architecture for epigenetic studies.

A close-up view of a DNA double helix structure, showing the intricate winding pattern of the strands. The background is blurred, emphasizing the DNA strands which have a textured, organic appearance.
A close-up view of a DNA double helix structure, showing the intricate winding pattern of the strands. The background is blurred, emphasizing the DNA strands which have a textured, organic appearance.
Phase One Overview

Multi-omics knowledge base with real-time monitoring capabilities.

Two people in lab coats collaborate in an office setting. One is seated and pointing at a computer screen displaying medical images, while the other stands nearby holding a tablet. Large windows reveal a view of greenery outside, creating a bright and professional environment.
Two people in lab coats collaborate in an office setting. One is seated and pointing at a computer screen displaying medical images, while the other stands nearby holding a tablet. Large windows reveal a view of greenery outside, creating a bright and professional environment.
Phase Two Focus

Methylation clock fine-tuning using novel architectures and techniques.

Two scientists in a laboratory, both wearing white lab coats and protective eyewear. The scientist in the foreground is using a pipette, while the one in the background is working on a computer. Various laboratory equipment and supplies are visible around them.
Two scientists in a laboratory, both wearing white lab coats and protective eyewear. The scientist in the foreground is using a pipette, while the one in the background is working on a computer. Various laboratory equipment and supplies are visible around them.
A person is undergoing a medical scan inside an MRI machine, with another individual assisting by adjusting their position. The scene appears clinical, with the MRI machine's interior emitting a soft pink glow. The assistant is wearing a blue checkered shirt and a white apron.
A person is undergoing a medical scan inside an MRI machine, with another individual assisting by adjusting their position. The scene appears clinical, with the MRI machine's interior emitting a soft pink glow. The assistant is wearing a blue checkered shirt and a white apron.
Causal Graphs

Building epigenetic-cellular function causal graphs for deeper insights.

Data Integration

Integrating diverse datasets for comprehensive epigenetic analysis.

Innovative Research in Epigenetics

Exploring advanced multi-omics methodologies for epigenetic insights and cellular rejuvenation.

A microscopic view showcasing cells arranged in layers, featuring various shapes and sizes. Predominantly pinkish-purple hues with darker circular structures scattered throughout suggest staining techniques often used in biological imaging. The image has clear, defined boundaries with a white background separating the sections.
A microscopic view showcasing cells arranged in layers, featuring various shapes and sizes. Predominantly pinkish-purple hues with darker circular structures scattered throughout suggest staining techniques often used in biological imaging. The image has clear, defined boundaries with a white background separating the sections.
gray computer monitor

《Deep Methyltransfer Learning for Skin Photoaging Prediction》 (Sci. Transl. Med. 2024)

Contribution: Epigenetic transfer framework achieving cross-species methylation translation (mouse→human, r=0.89)

Relevance: Methodology for multi-species data integration

《Blockchain-based Ethical Governance for Aesthetic AI》 (Nat. Biomed. Eng. 2025)

Contribution: Immutable intervention provenance chain recording epigenetic editing operations

Relevance: Foundation for ethical compliance

《Multi-omics Impact Atlas of Epigenome Editing》 (Cell Sys. 2023)

Contribution: First causal network map linking methylation editing → transcriptome → proteome, identifying novel COL3A1 activation target

Relevance: Mechanistic basis for intervention design

Research

Innovative solutions for multi-omics and methylation.

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